Project Grant R01HL179189
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA Program 93.837 - Cardiovascular Diseases Research) supports research into the biological basis of cardiac thick filament regulation. The central goal of this $715,378 award to The Ohio State University is to enhance the understanding of the basic mechanisms underlying the regulation of cardiac myosin structural states, which are critical for cardiac muscle contraction and heart function. The research aims to: 1)...
- The Project Grant award of $639,621 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM) to investigate mitochondrial signaling between cardiomyocytes and fibroblasts, and its role in cardiac fibrosis. The research aims to determine how cardiomyocyte-derived mitochondria mediate crosstalk with cardiac fibroblasts, which may underlie the...
- The University of Cincinnati was awarded a $698,432 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on "Stress Regulated RNA Degradation in Cardiac Hypertrophy." The project aims to establish the role of the UPF1 RNA helicase and the RBFOX1C RNA binding protein in regulating mRNA degradation in response to cardiac stress, and to determine the functional significance of this stress-regulated mRNA...
- This federal Project Grant award of $605,253 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by the University of Delaware to investigate the protective role of cardiac HSP90β ablation/inhibition for mitigating myocardial infarction and ischemia-reperfusion injury. The research aims to thoroughly examine if cardiac-specific HSP90β knockout confers cardioprotection, potentially by preserving mitochondrial membrane integrity....
- The federal Project Grant award of $678,803.00 was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to The Ohio State University. The funding supports research to investigate the role of the mitochondrial deubiquitinase USP30 in regulating microvascular endothelial cell function and its potential as a therapeutic target for acute inflammatory diseases like acute respiratory distress syndrome (ARDS) and sepsis. Key...
- The Project Grant award of $741,112.00 was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Ohio State University to investigate the impact of the adaptive immune system, specifically CD4+ T-cells, on cardiac electrophysiology and the development of heart failure. The research aims to elucidate the mechanisms by which CD4+ T-cells, when activated in the setting of heart failure, can directly induce cardiomyocyte dysfunction and cardiac...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded Cleveland State University a $890,723 Project Grant on January 15, 2025. The grant will fund research to develop novel mitochondria-targeting peptides (MTPs) as a potential therapeutic intervention for Barth syndrome, a serious genetic disorder characterized by cardiomyopathy. The project aims to address the critical need for effective treatments that...
- This $631,261 Project Grant award from the National Heart Lung and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) supports research at Rutgers University to elucidate the role of autophagy and mitochondrial quality control mechanisms, including mitophagy, in the senescence of cardiomyocytes and the development of cardiomyopathy. The research aims to determine how aging-induced suppression of autophagy promotes senescence in cardiomyocytes, leading to the accumulation of...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $385,000 in funding to the Rowan University School of Osteopathic Medicine (RowanSOM) to conduct research on the role of mitochondrial magnesium in regulating mitochondrial calcium uptake and permeability transition pore opening during ischemic reperfusion injury. The research aims to determine if impaired mitochondrial magnesium influx leads to mitochondrial...
- This Project Grant award of $167,400 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by Dr. Joshua Meisner at the University of Michigan to elucidate the mechanical and metabolic pathways underlying MYBPC3 hypertrophic cardiomyopathy. The research aims to develop novel in vivo and in vitro models to study the progression of this severe, adolescent-onset heart disease, and test the reversibility of pathology by targeting...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $694,466 to The Ohio State University to investigate the role of the mitochondrial BK (mitoBK) potassium channel in regulating cardiac function and protecting the heart from pathological hypertrophy. The research aims to test the hypothesis that cardiac mitoBK protects against cardiac hypertrophy by modulating mitochondrial biogenesis and function via signaling pathways involving PGC-1α and FOXO3A. The project will leverage the university's expertise in cardiac physiology and mitochondrial biology to advance the scientific understanding of how mitoBK contributes to cardioprotection. This 4-year award runs from September 2025 to June 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.5k | 9/4/25 |