Project Grant R01HL179187
- Federal Project Grant Award Summary Boston University Medical Campus received a $122,625 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) beginning June 1, 2025 and concluding May 31, 2027. The award funds research and development of novel small molecule therapeutics targeting oxidized sirtuin-1 (SIRT1) as a potential treatment for aortic aneurysms in Marfan Syndrome. The research deliverables...
- Federal Grant Award Summary Boston University Medical Campus received a $100,228 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 30, 2026, with a completion date of June 30, 2029. The grant funds research investigating the mechanisms of a conserved niche endothelial program that directs hematopoietic stem cell (HSC) migration into the bone marrow. The research aims to identify the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $1.44 million Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) on August 15, 2025, to develop mechanistic mathematical models of oxygen-dependent hemoglobin polymerization in sickle cell disease (SCD) at the single-cell level. The primary deliverables include the creation of computational models that explain heterogeneity in polymerization across individual...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Trustees of Boston University a $1,274,990 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) effective September 2, 2025, through May 31, 2029. The award supports development of the first high-speed wearable speckle contrast optical spectroscopy (SCOS) system with field-programmable gate array (FPGA)-based real-time processing for cuffless blood pressure monitoring. The research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Tufts University School of Medicine a $1.12 million Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on September 17, 2025, to conduct a multiethnic and multiomics analysis of longitudinal changes in DNA methylation (DNAM) and cardiovascular health. The four-year research initiative, concluding July 31, 2029, integrates longitudinal epigenome-wide DNAM data with behavioral, clinical, genetic,...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Baylor College of Medicine a $1.4 million Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 22, 2025, to develop a multi-modal dynamic risk prediction model for venous thromboembolism (VTE) and cancer-related bleeding (CRB) in ambulatory cancer patients. The research addresses the critical clinical gap in hemostatic risk prediction that currently prevents widespread adoption of...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $232,836 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded December 1, 2025, with completion targeted for November 30, 2027. The award supports research on biomarkers of ischemic risk in adults with sickle cell disease (SCD), utilizing non-invasive quantitative neuroimaging methods to investigate cerebral oxygen...
- Federal Grant Award Summary The University of Michigan received a $191,629 Project Grant awarded on May 15, 2026, by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a five-year research initiative (through April 30, 2031) addressing venous thromboembolism (VTE) prevention and management in pregnant and postpartum patients with sickle cell disease (SCD), a medically vulnerable population experiencing 10- to...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Colorado–Denver a Project Grant totaling $111,626 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period August 1, 2025, through July 31, 2027. This research initiative focuses on investigating macrophage populations as a therapeutic target to attenuate pulmonary hypertension (PH) associated with sickle cell disease (SCD). The project will deliver...
- Federal Grant Award Summary Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded Emory University a Project Grant totaling $646,383 under the Cardiovascular Diseases Research program (CFDA 93.837). The award was obligated on September 15, 2025, with an ultimate completion date of June 30, 2030. Research Scope and Deliverables: This project investigates red blood cell (RBC) transfusion survival and effectiveness in recipients with sickle cell disease (SCD), a clinical...
Boston University Medical Campus received a $1,668,912 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 15, 2026, with completion targeted for May 31, 2028. The STOP-SCD-VTE study will deliver real-world evidence research services examining anticoagulation outcomes and clinical practice patterns for patients with sickle cell disease (SCD) and venous thromboembolism (VTE). The research team will utilize three clinical registries—TriNetX, GRNDAD (Globin Regional Data and Discovery), and the ASH Research Collaborative DataHub—to investigate practice variation in long-term anticoagulation treatment and evaluate whether implementing American Society of Hematology clinical guidelines and direct oral anticoagulants reduce VTE recurrence, vasoocclusive events, cardiac complications, and mortality in adults with SCD. The deliverables include comprehensive health services and clinical outcomes research analysis employing advanced statistical methods including causal mediation analysis and target trial emulation. The multidisciplinary research team will produce evidence addressing the comparative efficacy and safety of vitamin K antagonists (warfarin) versus direct oral anticoagulants (apixaban, rivaroxaban) for SCD patients, with findings intended to inform clinical practice patterns and reduce treatment disparities in this high-risk population where VTE recurrence increases mortality risk nearly threefold.Summary of Federal Project Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 6/16/26 |