Project Grant R01HL178985
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $809,307 Project Grant to Icahn School of Medicine at Mount Sinai, effective July 1, 2026 through March 31, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). This initiative, titled "Am I At Risk? Health Empowerment Through Population Genomic Screening for Transthyretin Amyloidosis," will deliver population-based genomic screening and community health services to identify...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $763,862 Project Grant to Icahn School of Medicine at Mount Sinai (award date: July 1, 2026; completion date: March 31, 2031) under the Cardiovascular Diseases Research program (CFDA 93.837). The research focuses on elucidating the metabolic control of immune cell function in atherosclerosis development. Specifically, the project investigates the role of methylmalonic acid (MMA)—a byproduct of...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Virginia a $732,261 Project Grant on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on the genetic factors underlying central obesity. The project, "Leveraging Large-Scale Multi-Ethnic, Multi-Omic Data for Functional Analysis of Central Obesity Loci," will identify putative causal genes associated with central...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $1,175,924 (awarded April 1, 2026; completion January 31, 2033) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct basic research on hemogenic mesoderm heterogeneity, regulation, and function. Under the direction of Dr. Sturgeon, the research program will delineate the molecular and transcriptional mechanisms by...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $570,666 to Icahn School of Medicine at Mount Sinai on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop an advanced base editor reengineering platform aimed at enhancing gene editing specificity and selectivity. The project will deliver a streamlined engineering platform that integrates naturally occurring oligonucleotide binding modules into deaminase active...
- Federal Project Grant Award Summary Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $519,504 under the Cardiovascular Diseases Research program (CFDA 93.837) for the period September 15, 2025, through August 31, 2028. The award funds development and pilot testing of an integrated behavioral intervention combining asthma self-management support with cognitive behavioral therapy for older adults...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $816,472 (awarded August 1, 2025, with completion targeted for May 31, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate advanced artificial intelligence models for improving cardiovascular risk prediction and treatment response assessment in obstructive sleep apnea (OSA) patients. The research...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Tufts University School of Medicine a $1.12 million Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on September 17, 2025, to conduct a multiethnic and multiomics analysis of longitudinal changes in DNA methylation (DNAM) and cardiovascular health. The four-year research initiative, concluding July 31, 2029, integrates longitudinal epigenome-wide DNAM data with behavioral, clinical, genetic,...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $713,421 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 3, 2025, with completion targeted for June 30, 2029. This research initiative investigates the regulation of thin filament architecture by Cyclase-Associated Protein 2 (CAP2) in cardiac health and myopathy, with the objective of elucidating mechanisms...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $170,892 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) to Icahn School of Medicine at Mount Sinai on June 22, 2026, for a five-year performance period concluding May 31, 2031. This training grant supports Dr. Oren Cohen's development as an independent investigator through structured, mentored instruction in machine learning (ML) and artificial intelligence (AI)-based clinical...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $856,812 (awarded June 22, 2026; completion date February 28, 2031) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct an integrative genomic research study. The project will identify genetic variants and pathways that explain the heterogeneity in obesity and cardiometabolic risk, leveraging the metabolically healthy obese (MHO) and metabolically obese normal weight (MONW) phenotypes as analytical tools. The research will perform genome-wide association studies (GWAS) and tissue enrichment analyses across large multi-ancestry cohorts to discover genetic loci that disentangle obesity from cardiovascular complications and define distinct genetic subtypes with differential disease risk signatures. The deliverables include comprehensive genomic analyses identifying genes and biological pathways governing obesity independent of cardiometabolic dysfunction, tissue-level mechanistic insights into how different genetic variants regulate body weight through distinct physiological mechanisms, and the characterization of genetic subtypes each associated with unique patterns of adiposity and metabolic risk. The study builds on preliminary findings of 62 genomic loci and 266 variants with protective cardiometabolic signatures, and eight identified genetic subtypes, advancing foundational understanding of obesity heterogeneity to inform precision medicine approaches and cardiovascular disease prevention strategies.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $856.8k | 6/26/26 |