This $590,283 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of feedback-controlled closed-loop manufacturing processes to improve the robustness and reproducibility of differentiating human pluripotent stem cells into cardiomyocytes. The 4-year project aims to identify failure modes in 2D and 3D cardiomyocyte differentiation through single-cell transcriptomics and epigenomics, develop genetic and epigenetic sensor cell lines to monitor the process, and test modulation of cardiac developmental pathways to enhance the reliability of cardiomyocyte production in scalable manufacturing platforms. The research is being conducted by the University of Wisconsin - Madison, operating as the Research and Sponsored Programs division of the University of Wisconsin System.
Generated 3/4/25, 6:03 AM