This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $740,317 to The Washington University to conduct research on the regulation of primary and secondary alveologenesis (the final phase of lung development) by FGF signaling pathways. The research aims to identify the cellular mechanisms by which FGF signaling regulates cell proliferation, differentiation, and death during the first and second stages of...
This Project Grant award of $583,233 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Washington University in St. Louis supports research to investigate the role of circulating osteopontin and innate immune cell CD44 in remote lung inflammation following acute kidney injury. The key goals are to: 1) determine which osteopontin domains and cleavage are required to induce remote lung inflammation, 2) examine whether CD44 in lung innate...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,659,996 to the University of Southern California (USC) to conduct research on the role of the protein PDLIM2 in regulating alveolar macrophages and their function in lung innate immunity, inflammation, and diseases. The key objectives are to determine the physiological and pathophysiological significance of the PDLIM2/CD80/PD-L1 signaling pathway in alveolar...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $148,568.00 to Mayo Clinic to investigate the role of pleural mesothelial cells in lung injury, repair, and regeneration. The project will utilize lineage-tracing experiments in mouse models to study the function of these cells in the context of lung fibrosis and regeneration. The research aims to elucidate the signaling...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA Program 93.837 Cardiovascular Diseases Research) provides $480,990 to the University of Illinois to conduct research on the role of aerocytes, a recently identified capillary endothelial cell population, in regulating alveolar regeneration following lung injury. The research aims to establish the central role of aerocytes and the signaling molecule R-spondin3 in guiding regenerative alveolar remodeling, with the...
This federal Project Grant award for $595,286.00, provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate a previously unappreciated mechanism of regulating collagen clearance in the lungs. The research seeks to delineate the pathways and upstream/downstream mechanisms governing a cellular homeostatic feedback loop that senses collagen synthesis and regulates its clearance. This work will use mouse...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $156,665 to The Trustees of the University of Pennsylvania to support research on regenerative processes in the lung following severe injury. The key focus is examining the role of mesenchymal cell plasticity and signaling, particularly involving Notch-mediated paracrine signaling within the alveolar niche, in driving...
This $203,974 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a research project to investigate the effects of normal and diseased extracellular matrix (ECM) on the self-renewal and differentiation of airway basal epithelial cells. The project leverages novel tools developed by the co-PIs, including "inside-out" airway organoids and ECM hydrogels derived from normal and...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of North Carolina at Chapel Hill to investigate the role of regulatory T cells (Tregs) and glucocorticoid signaling in the resolution of acute lung injury. The $775,992 award, effective February 1, 2025 through November 30, 2029, will enable researchers to determine the function of Treg glucocorticoid receptor signaling and the...
This Project Grant award of $1,546,880 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the regulatory mechanisms underlying the development of myofibroblasts, a key driver of pulmonary fibrosis. The award to the University of Pittsburgh aims to determine the role of E-box motif accessibility and E-box transcription factor expression in regulating the myofibroblast program in idiopathic pulmonary fibrosis. The...