The National Heart, Lung, and Blood Institute (NHLBI) awarded a $792,498 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to the Trustees of Indiana University (IU Indianapolis) to conduct research on the regulation of hematopoietic stem cells under low oxygen tension. The central goal of the research is to understand the signaling and metabolic alterations in hematopoietic stem cells under hypoxic conditions and explore the potential to manipulate these processes in normoxic conditions to improve stem cell functionality. The 4-year project, with a completion date of Nov 30, 2028, will investigate how hypoxia activates key transcriptional and metabolic pathways to facilitate hematopoietic stem cell self-renewal and prevent oxidative damage or differentiation. The findings have the potential to improve hematopoietic cell transplantation and gene therapy applications.
Generated 3/4/25, 8:35 AM