The National Heart, Lung, and Blood Institute (NHLBI) awarded a $779,771 project grant (93.837 Cardiovascular Diseases Research) to The Medical College of Wisconsin, Inc. (MCW) to investigate the cardiometabolic impacts of gender-affirming hormone therapy (GAHT) in transmasculine young adults. The project aims to: 1) Determine the effects of GAHT initiation on vascular endothelial and cardiometabolic health, including changes in endothelium-dependent vasodilation, vascular stiffness, and cardiometabolic biomarkers; and 2) Examine GAHT's impact on sex-hormone receptor expression, endothelium-dependent vasodilation, and nitric oxide production in resistance arterioles. The findings are expected to provide critical information on the molecular and physiological vascular and cardiometabolic effects of GAHT in this underserved population, informing discussions around cardiovascular disease disparities. The award period is from February 1, 2025 to November 30, 2028.
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