The National Heart, Lung, and Blood Institute (NHLBI) awarded a $739,362 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Washington University Office of Sponsored Research Services Division in St. Louis, Missouri. The funding supports research to investigate a novel genetic variant in the COQ6 gene and its impact on the pathophysiology of pneumococcal sepsis. The project aims to characterize the inflammatory and physiological derangements in sepsis caused by this genetic variant, analyze associated metabolomic and transcriptomic profiles, and test potential therapies to improve survival. As part of this project, Indiana University is receiving a $55,000 sub-award to provide biostatistical research support and analysis services. The project was initiated on August 26, 2024 and is scheduled for completion by July 31, 2028.
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