Project Grant R01HL177430

Award Date 5/1/25
Completion Date 1/31/29
Dollars Obligated $542K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Georgia, USA
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The National Heart, Lung, and Blood Institute (NHLBI) awarded Emory University a $542,442 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to develop and validate a new mechanical biosensor technology called MCATS that can rapidly detect heparin-induced thrombocytopenia (HIT) using small blood samples. The key products and services to be delivered through this 4-year project include:

  1. Investigating the signaling link between HIT activation and the mechanical forces generated by human platelets.
  2. Optimizing the MCATS technology to enhance the signal obtained from human platelets for improved HIT detection.
  3. Validating and benchmarking the MCATS assay against standard laboratory tests for HIT diagnosis, such as ELISA and SRA.

The overarching goal is to develop a rapid, accessible, and accurate mechanical assay that can diagnose HIT, a potentially life-threatening adverse reaction to the widely-used anticoagulant heparin. If successful, this technology could substantially improve HIT detection capabilities and patient outcomes.

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