The Broad Institute, Inc. was awarded a $817,208 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research to investigate the genetic basis and underlying mechanisms of heart failure, a major global health challenge. The Broad Institute will apply high-throughput functional genomics approaches, including cell painting and Perturb-seq, to systematically analyze the impact of genetic risk variants associated with heart failure identified through genome-wide association studies. This will enable rapid functional validation of novel heart failure genes and pathways, generating testable hypotheses for future investigation using engineered heart tissues and animal models. The results are expected to accelerate the identification of new therapeutic targets for heart failure.
Generated 3/4/25, 7:25 AM