This $596,179 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports a five-year research plan to elucidate the role of macropinocytosis, a cellular process, in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The research aims to determine whether macropinocytosis deficiency can attenuate fibrosis in animal and cell culture models of pulmonary fibrosis, explore how macropinocytosis-mediated amino acid uptake regulates profibrotic gene expression in activated lung fibroblasts, and assess the potential anti-fibrotic effects of macropinocytosis inhibitors. The grant was awarded to Baylor College of Medicine, a leading academic medical center, to conduct this comprehensive research program focused on understanding the molecular mechanisms underlying IPF and exploring potential therapeutic approaches targeting macropinocytosis.
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