This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,364 to The Broad Institute, Inc. to conduct research focused on integrating novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adults aged 18-39 years. The key objectives of this 2-year project are to: 1) identify novel ambulatory blood pressure patterns that capture dynamic responses to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $619,882 to the Regents of the University of Michigan to conduct a clinical trial investigating the mechanisms behind a polygenic risk score (PRS) that predicts individual patient response to beta-blocker therapy for heart failure with reduced ejection fraction (HFREF). The study aims to determine differences in the pharmacodynamic and...
This federal Project Grant award of $246,776.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop novel methods for creating and validating polygenic scores (PS) that can predict medication response in African American populations. The goal is to create ancestry-robust PS tools that account for local genetic ancestry context, improving their predictive performance for non-European populations. The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $2,042,978 to the University of South Alabama to investigate the molecular mechanisms by which the protein progranulin regulates endothelial function and blood pressure control. The key objectives are to determine how reduced endothelial progranulin levels contribute to the development and progression of hypertension through...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $362,250 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to evaluate whether treating elevated blood pressure in the inpatient setting impacts patient outcomes. The project, titled "Evaluating Whether Treating Elevated Blood Pressure in the Inpatient Setting Impacts Patient Outcomes: The ACT-BP Pilot," aims to...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) is funding research to investigate the role of arterial baroreceptors in hypertension. The $136,350 award to the Georgia State University Research Foundation aims to unravel the genetic identity of arterial baroreceptors and link their gene expression to neuronal function during blood pressure regulation. During the initial K99 career...
This Project Grant awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $147,486 to Baylor College of Medicine to conduct research aimed at improving genetic testing for cardiovascular disease (CVD). The key objectives are to: Study the genetics of CVD and lipoprotein(a) (Lp(a)) across diverse and mixed-ancestry populations using novel tools that appropriately evaluate ancestry. This includes evaluating the role of linkage...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,709,341.45 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of Columbia University in the City of New York to conduct a 1-week daily diary study. The study aims to estimate the influence of intersectional anticipated and vicarious stigma on home blood pressure, and examine potential mediating mechanisms such as salivary stress biomarkers and anxiety. The research will recruit a...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,092,000 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Medical College of Wisconsin, Inc. to conduct research on the intersection of the PPARG-RHOBTB1-CULLIN-3 pathway and the renin-angiotensin system, and their role in blood pressure regulation, vascular function, and arterial stiffness. The 7-year project aims to elucidate the molecular and physiological mechanisms controlling vasomotor function, arterial...
This Project Grant award of $2,340,322, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will fund a prospective, multicenter cohort study of 1,268 liver transplant recipients (LTRs) over 2 years, with outcomes tracked up to 5 years post-transplant. The study aims to: Determine the net clinical benefit of blood pressure-lowering on target organs in LTRs, Evaluate if cardiac biomarker levels can improve...