Project Grant R01HL176797
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) is funding the development of a "Fail Safe, High Output Failing Fontan Pump" to provide mechanical circulatory support for individuals with congenital heart disease and single ventricle physiology. The $320,838 award to Perfusion Solutions Inc. (UEI: TF8CUC65VLG5) supports the hydraulic design refinement and component development of a...
- This Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports the development of a bearingless flux reversal motor for a neonatal and pediatric extracorporeal life support application. The $870,467 award to Ension Inc. aims to address shortcomings of the currently available pediatric blood pump, the Abbott Pedimag, by developing an innovative bearingless (magnetically levitated) motor...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- The National Heart, Lung, and Blood Institute (NHLBI), under the federal Cardiovascular Diseases Research program (CFDA 93.837), awarded a $306,643 project grant to Mira Medical, LLC to develop a new extracorporeal membrane oxygenation (ECMO) pump designed to efficiently accommodate the low flow rates needed for pediatric and neonatal patients. The project aims to design, develop, and test a low-flow ECMO pump capable of operating at flow rates from 0.05 to 0.5 L/min, which is an order of...
- This Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), funds the development of Heartpoint Global's IntelliSent - a minimally invasive, adjustable pulmonary flow restrictor system for pediatric and congenital heart disease patients. The $1,771,084 award supports efforts to (1) downsize the IntelliSent device to be suitable for patients from birth, including preclinical testing, (2) complete...
- This $321,679 Project Grant, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development and testing of an expandable pediatric pulmonary heart valve device. The research aims to create a valve that can grow larger with the patient to address the challenge of multiple open-heart surgeries required for infants and children with severe heart valve defects. The key research activities include optimizing the...
- Percassist Inc. received a $663,129 Project Grant award from the National Heart Lung and Blood Institute of the Department of Health and Human Services. The award was made under the Cardiovascular Diseases Research program (CFDA 93.837), which supports heart and vascular research. The grant funds the development of a percutaneous ventricular assist device for chronic heart failure patients. Specifically, Percassist will design and test a balloon catheter implant that can be delivered minimally...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,024,635 project grant to Corvion, Inc. to develop a Totally Implanted Left Ventricular Assist Device (TI-LVAD). The TI-LVAD aims to reduce complications and enhance quality of life for heart failure patients by eliminating the need for a percutaneous driveline and external power supply. The key innovation is a hybrid magnetically levitated blood pump that requires...
- This $6,487,175.00 Project Grant awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) supports preclinical readiness for a pediatric heart assist system to treat congenital heart failure in infants and children. The award, effective March 1, 2025 through February 28, 2029, is made to Cornell University's Office of Sponsored Programs to conduct this critical medical research and development. The project aims to advance a novel heart assist...
- This federal Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $769,994 to investigate the impact of left ventricular assist device (LVAD) implantation on cerebral hemodynamics and cognition. The University of Pennsylvania will conduct the research, which aims to clarify the relationship between LVAD physiology and neurovascular health in order to identify hemodynamic metrics that can be used to...
The $784,203 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting the development and testing of a small, durable, and hemocompatible centrifugal blood pump for use in children aged 1-11 years (weighing approximately 10-35 kg) with heart failure. The immediate goal is to test and refine the "PSU Child VAD" (ventricular assist device) prototype through a series of 30-day in-vivo studies to validate the design and determine if it meets the required specifications. This includes assessing hemodynamic performance and biocompatibility, with the aim of minimizing thrombosis, von Willebrand factor degradation, and hemolysis while maximizing hydraulic efficiency. The 4-year award period runs from September 1, 2025 to June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $784.2k | 8/20/25 |