Project Grant R01HL174975
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,024,635 project grant to Corvion, Inc. to develop a Totally Implanted Left Ventricular Assist Device (TI-LVAD). The TI-LVAD aims to reduce complications and enhance quality of life for heart failure patients by eliminating the need for a percutaneous driveline and external power supply. The key innovation is a hybrid magnetically levitated blood pump that requires...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $455,826 to conduct a double-blind, randomized, placebo-controlled trial to determine the effects of chronic sildenafil administration on vascular remodeling during left ventricular assist device (LVAD) support. The study aims to assess the impact of sildenafil, a phosphodiesterase-5 inhibitor, on aortic stiffness, carotid...
- The University of Texas at Dallas received a $608,874 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on improving outcomes for patients with ventricular assist devices (VADs). The key products and services to be delivered under this 4-year grant include: Identifying pre-implant biomarkers that can predict post-VAD implantation infection risk. Determining if the high infection rates in VAD recipients are...
- The $784,203 Project Grant awarded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is supporting the development and testing of a small, durable, and hemocompatible centrifugal blood pump for use in children aged 1-11 years (weighing approximately 10-35 kg) with heart failure. The immediate goal is to test and refine the "PSU Child VAD" (ventricular assist device) prototype through a series of 30-day in-vivo studies to validate the design...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- This National Institute of Nursing Research (NINR) Project Grant (CFDA 93.361) award of $971,652 to The Trustees of Columbia University in the City of New York, with sub-awards to the University of North Carolina at Charlotte and The Johns Hopkins University, aims to study patient activation, cognition, and self-management behaviors in patients with left-ventricular assist devices (LVADs). The research project will examine the relationships between patient activation, cognitive function, LVAD...
- This federal Project Grant award of $664,458, provided by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders), supports research to develop a novel non-invasive optical imaging technique for the prehospital detection of large vessel occlusion (LVO) in acute stroke patients. The University of Pennsylvania, the grant recipient, is validating this optical cerebral hemodynamic monitoring approach...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) will fund a study to investigate the impact of selective vagal neuromodulation on heart failure indices. The 2-year project, with a start date of September 1, 2025, will be conducted by the University of Colorado-Denver. The research aims to better understand the neural interface by studying the effects of selective activation of cholinergic (efferent)...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $174,420 to The Trustees of the University of Pennsylvania to conduct research aimed at improving lung transplantation outcomes. The key objectives are to investigate the impact of centralizing deceased organ donor management at specialized Donor Care Units (DCUs) and assess the consequences for diverse stakeholders in the national donation and transplantation...
- The federal Project Grant award by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $534,761 to the University of California, Los Angeles (UCLA) to develop "Magnetoelastic Vascular Grafts" (MVGs). The MVGs are a transformative platform technology that can wirelessly and continuously monitor blood flow and detect stenosis (narrowing) in vascular grafts, a common issue affecting nearly 40% of grafts within 2 years of implantation. The...
This federal Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $769,994 to investigate the impact of left ventricular assist device (LVAD) implantation on cerebral hemodynamics and cognition. The University of Pennsylvania will conduct the research, which aims to clarify the relationship between LVAD physiology and neurovascular health in order to identify hemodynamic metrics that can be used to personalize and improve long-term outcomes for LVAD patients. The research leverages transcranial Doppler ultrasonography to continuously measure cerebral blood flow and quantify critical measures of cerebrovascular health, including cerebral autoregulation and cerebrovascular reactivity. This work seeks to address the significant neurological complications associated with LVAD implantation and optimize outcomes for this patient population. The award period runs from Sep 2025 to Jul 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $770.0k | 9/4/25 |