Project Grant R01HL176781
- The National Heart, Lung, and Blood Institute, through the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $697,296 project grant to The Trustees of Columbia University in the City of New York, Health Sciences Division, to investigate the role of N6-methyladenosine (m6A) epitranscriptomic mRNA modification in the generation and regeneration of the hematopoietic stem cell (HSC) niche within the bone marrow. This 4-year project aims to characterize how m6A regulates the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
- The federal Project Grant award of $701,890.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the molecular mechanisms by which the cancer drug sunitinib induces vascular dysfunction. The University of Illinois in Chicago is conducting this research, which aims to better understand sunitinib's effects on the endothelial cells that line blood vessels, in order to mitigate the risk of cardiovascular toxicity...
- This Project Grant award of $796,189.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to define the dynamics of neutrophil subpopulations and their role in inflammatory lung injury and repair. The study aims to identify the distinct functions of the CXCR2 and CXCR4 chemokine receptors in regulating neutrophil trafficking and activation during acute lung inflammation, with the goal of developing...
- The federal Project Grant award titled "NICHE-SPECIFIC ENDOTHELIAL MECHANISMS REGULATING THE EXTRAVASATION OF HEMATOPOIETIC STEM CELLS" is funded by the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837). The $734,607 award, effective May 1, 2025 through February 28, 2030, supports research at Boston Medical Center Corporation to elucidate the key endothelial mechanisms that direct circulating hematopoietic stem cells across the...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $146,922.00 to the Albert Einstein College of Medicine to investigate genotype-environment interactions that drive dysfunction in hematopoietic stem and progenitor cells (HSPCs). The research aims to decipher how HSPC dysregulation, a major driver of myeloid malignancies like myelodysplastic syndromes (MDS), is influenced by the interplay between genetic...
- This federal Project Grant award for $802,301, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research by Weill Medical College of Cornell University to investigate the mechanisms that control the bone marrow "niche" environment and its role in expanding mutated blood stem cells that increase the risk of cardiovascular disease and cancer. The research aims to identify signaling pathways that can be targeted to prevent...
- This $147,486.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of high-fat diet in hematopoiesis (blood cell formation) and clonal hematopoiesis, a condition associated with increased risk of myeloid diseases like myelodysplastic syndrome and acute myeloid leukemia. The award was made to the Regents of the University of Michigan, Ann Arbor for a project period running from Jul 9,...
- This federal Project Grant award of $422,125 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to assess whether multi-omic data of myeloid-derived suppressor cells (MDSCs) can improve sepsis endotyping and predict clinical trajectories in chronic critical illness (CCI) after sepsis. The overarching goal is to better understand the role of "pathologic myelopoiesis" and MDSC...
- This federal Project Grant award of $344,111.00 was provided by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to Loyola University of Chicago's Health Sciences Campus division. The grant supports research aimed at understanding the fundamental biological mechanisms of myelodysplastic syndromes (MDS), a group of bone marrow failure diseases that can transform into acute myeloid leukemia. The research focuses on targeting "panoptotic pathways" -...
This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $461,132 to the University of Illinois to determine the mechanisms by which myeloid-derived suppressor cells (MDSCs) can promote the recovery of the bone marrow endothelial niche after chemotherapy and radiation treatment. The key objectives are to: 1) investigate how Jagged1-expressing pro-MDSCs enhance hematopoietic recovery after preconditioning, 2) test the potential of pro-MDSCs and Jagged1-coated biomimetic nanoparticles to restore the bone marrow niche and support hematopoietic regeneration in relevant animal models. This award aims to advance understanding of how the interplay between bone marrow niche cells and pro-MDSCs can promote hematopoietic recovery after myelosuppressive treatments, with the goal of developing cell-based and cell-free therapies to treat acquired bone marrow failure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $461.1k | 8/11/25 |