This $542,663 Project Grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the mechanistic role of the small RhoE GTPase in regulating cardiac fibrosis following myocardial infarction. The research aims to define the functional significance of RhoE in post-MI cardiac remodeling and uncover novel mechanisms by which RhoE modulates extracellular matrix protein expression and myofibroblast apoptosis. The project will utilize comprehensive experimental approaches and genetically-modified animal models to explore this potential adaptive anti-fibrotic signaling pathway, with the goal of developing novel therapeutic strategies to selectively mitigate chronic cardiac fibrosis without interrupting the acute wound healing response. The award was made to the Texas A&M University System Health Science Center and has a performance period from March 2025 through December 2029.
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