This Project Grant award for $798,958.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to Northwestern University. The award supports research to investigate the role of the integrated stress response in driving chronic lung allograft dysfunction after lung transplantation. The research aims to determine if early primary graft dysfunction induces chronic activation of the integrated stress response, which then impairs alveolar epithelial repair and predisposes patients to an increased risk of chronic lung allograft dysfunction. Key research activities include testing this hypothesis in murine models and analyzing human samples longitudinally after lung transplantation, with the goal of identifying targets for therapy that can be administered at the time of transplant to reduce the long-term risk of chronic allograft dysfunction. The award period is from January 1, 2025 to November 30, 2029.
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