The National Heart, Lung, and Blood Institute (NHLBI) awarded a $807,067 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Virginia (UVA) to pioneer the quantitative documentation of human respiratory kinematic profiles. The goal is to identify novel respiratory kinematic physiomarkers that can improve prediction of severe respiratory failure beyond conventional monitoring. UVA will record the kinematic properties of the mature respiratory system in a large cohort of adults during emergency room visits, using a newly developed wearable sensor technology called Analysis of Respiratory Kinematics (ARK). The project will also validate the use of ARK in a cohort of premature neonates. The research aims to elucidate high-dimensional kinematic phenotypes that can serve as early warning signs of respiratory deterioration, enabling timely treatment, reduced ventilator use, and lives saved. This award represents a significant advancement in the federal government's efforts to address the critical challenge of predicting and preventing respiratory failure.
Generated 3/4/25, 5:33 AM