This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $703,358 to Tufts Medical Center to study the role of the FHOD3 gene variant in cardiac autophagy and remodeling. The research aims to investigate how the FHOD3V1151I mutation impacts autophagy and the development of hypertrophic cardiomyopathy, a leading cause of heart failure. Key aspects include comparing the effects of autophagy stimulation and inhibition in FHOD3V1151I mouse models, assessing the interaction with an MYBPC3 mutation known to impair autophagy, and evaluating the impact on extracellular vesicle production. This work has the potential to elucidate new mechanisms underlying genetic contributions to cardiomyopathy and inform personalized treatment strategies. The grant term runs from August 2024 through May 2028.
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