Project Grant R01HL174858
- This federal Project Grant award of $738,154 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop a novel mortality risk prediction model to accurately assess mortality risk for ICU patients across all patient groups. The key objectives are to: (1) identify mechanisms of systematic measurement error in commonly used ICU mortality risk prediction models, and (2) develop an accurate ICU mortality risk prediction model. The project will...
- The Regents of the University of Michigan were awarded a $207,342 Project Grant from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The goal of this 5-year program is to enhance research training and career development opportunities for Emergency Medicine (EM) resident investigators at the University of Michigan. The program will recruit and train 2 outstanding EM resident trainees annually, providing them with 12...
- This federal Project Grant award, valued at $272,226.00, was granted by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The project aims to determine how clinician and scheduling characteristics impact patient outcomes, and explore the moderating effect of patient characteristics on these relationships, for mechanically ventilated adults in intensive care units. The project will conduct a novel secondary analysis utilizing a unique...
- This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $186,408 to the University of Washington to develop robust models that identify patients at high risk for persistent hypoxemic respiratory failure (HRF). The goal is to improve the ability to distinguish patients with persistent HRF early, which is critical for enrolling the highest-risk patients in clinical trials for new HRF...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,061,189 to the Regents of the University of Michigan to conduct research on immune crosstalk in lung injury and fibrosis. The key objectives are to study epithelial cell regulation of fibrosis and its interaction with myeloid cells, uncover mechanisms for impaired innate immunity against gram-positive infections in fibrosis, test delivery of targeted therapeutics...
- This Project Grant award, titled "DEVELOPING IMPLEMENTATION SCIENCE EXPERTISE IN CARDIOVASCULAR HEALTH SERVICES RESEARCH", is funded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $133,085 grant, awarded on September 1, 2025, supports research activities at the University of Michigan to improve the management of anticoagulant medication and increase the use of evidence-based outpatient treatment for low-risk...
- This federal Project Grant award, valued at $518,613.00 and granted by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to define the molecular basis of thrombospondin-1-induced fibro-fatty diaphragm remodeling, a driver of obesity-associated respiratory dysfunction. The research, conducted by the Regents of the University of Michigan, aims to investigate the role of the matricellular protein thrombospondin-1 in promoting...
- This federal Project Grant award of $169,344 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance the management of critically ill adults with non-ARDS acute hypoxemic respiratory failure (NAHRF). The key objectives are to: 1) Develop clinical prediction models for mortality in NAHRF patients; 2) Apply machine learning to detect NAHRF subphenotypes associated with differential clinical outcomes; and 3) Use sequencing-based whole...
- This $165,980 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports a computational analysis of hemodynamics in patients with renal artery fibromuscular dysplasia (FMD). The goal is to investigate the impact of large vessel and small vessel disease on FMD versus atherosclerotic renal artery stenosis (ARAS) patients through hemodynamic indices like fractional flow reserve (FFR) and index of microvascular resistance...
- This Project Grant, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), provides $196,245 to the Regents of the University of Michigan to develop and validate a multi-dimensional proteomic signature to predict treatment failure in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). The 4.5-year project aims to determine FVC trajectory and cumulative incidence of treatment failure across CTD-ILD subtypes,...
This $1,380,474 federal Project Grant awarded on September 24, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to improve the care of patients with acute heart and lung diseases. The University of Michigan will develop data-driven models to support improved decision-making for intensive care unit (ICU) triage and inpatient bed assignment. The project will identify determinants of triage and bed assignment, develop a clinical decision support model to estimate ICU care benefit, and create an optimization model for inpatient bed assignment. These models will be evaluated in emulated pragmatic trials to help reduce preventable hospital deaths among patients with acute cardiovascular and pulmonary conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 9/23/25 |