Project Grant R01HL174633
- This Project Grant award of $565,834 from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the long-term impact of early-life respiratory syncytial virus (RSV) infection on the development of childhood asthma. The research will focus on understanding how RSV infection can cause epigenetic modifications in lung epithelial cells that lead to persistent changes in the lung's...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate how early-life inflammation and viral infections shape the development and function of type 2 innate lymphoid cells (ILC2s) in the lungs, and their role in driving childhood asthma susceptibility. The $740,709 award to the University of Utah is intended to define the cellular and molecular mechanisms by...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $1,061,189 to the Regents of the University of Michigan to conduct research on immune crosstalk in lung injury and fibrosis. The key objectives are to study epithelial cell regulation of fibrosis and its interaction with myeloid cells, uncover mechanisms for impaired innate immunity against gram-positive infections in fibrosis, test delivery of targeted therapeutics...
- The federal Project Grant award, titled "MicroRNAs in Airway Smooth Muscle Function and Asthma," was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $616,814 award, with a start date of January 15, 2025 and a completion date of November 30, 2028, supports research at the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) to investigate the role of microRNAs in regulating...
- This federal Project Grant award, valued at $801,648.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Illinois in Chicago. The grant aims to uncover the molecular mechanisms responsible for the protective effects of early endotoxin exposure against asthma. The key objectives are to investigate the role of the MIZ1 protein in mediating the protective effects of endotoxin against allergic asthma, determine the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $690,626 to the Regents of the University of Michigan to conduct research on the role of type I interferon signaling in modulating acute lung injury and regeneration of the alveolar epithelium. The key objectives are to: 1) identify the molecular effectors linking interferon signaling to cell cycle arrest in respiratory epithelial cells, 2)...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $754,729 to the University of Pittsburgh to investigate the mechanisms by which respiratory viral infections, including COVID-19, can lead to persistent lung inflammation and damage. The research aims to understand how viral antigen persistence in pulmonary endothelial cells drives chronic activation of CD8+ T cells, leading to long-term pulmonary sequelae. The...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $760,759 to the University of Illinois to examine the immunoregulatory role of a specific dendritic cell subset, CX3CR1+CDC2, in allergic lung inflammation. The project aims to characterize the anti-inflammatory functions of this cell population and its impact on regulatory T cell development and the resolution of allergic asthma symptoms. Through the use of novel...
- The federal Project Grant award titled "Targeting the Stromal Niche for Tissue-Resident Lymphocytes in Asthma" was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $636,843 award will fund research to characterize a targetable stromal factor that alters immune cell accumulation in the lung and define the downstream effects on airway epithelial cells. The project aims to leverage novel genetic tools, human...
This $680,562 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research investigating the long-term lung epithelial alterations resulting from early-life respiratory syncytial virus (RSV) infection. The research aims to determine the mechanisms by which early-life RSV infection predisposes individuals to developing asthma later in life, focusing on the role of innate cytokines like IL-1β and IL-33 in driving epigenetic modifications and phenotypic changes in lung epithelial cells. The 5-year project, running from Sep 15, 2025 to Jun 30, 2030, is led by researchers at the University of Michigan. The findings may help elucidate the link between severe RSV bronchiolitis in early childhood and increased asthma risk, potentially informing the development of new therapeutic interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $680.6k | 9/9/25 |