Project Grant R01HL174439

Award Date 7/1/24
Completion Date 6/30/29
Dollars Obligated $484K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Reno, NV 89557, USA
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The primary awardee, the University of Nevada, Reno (UNR) Sponsored Projects Division, will utilize novel live-cell imaging techniques to observe in real-time the relationship between sympathetic neuron firing rates and NPY release, determine if neuro-cardiac junction formation enhances NPY-containing vesicle trafficking and synaptic localization, and investigate whether sympathetic neurons from a hypertensive disease model exhibit increased baseline excitability and NPY release. These studies aim to transform the understanding of dynamic regulation of vesicular trafficking and neuropeptide release in sympathetic neurons, with potential implications for detecting and treating cardiovascular diseases.

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