Project Grant R01HL174409

Award Date 7/22/24
Completion Date 4/30/25
Dollars Obligated $2.6M
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Washington, DC, USA
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The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,593,112 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to George Washington University to investigate the role of the melanocortin 4 receptor (MC4R) in regulating breathing and treating obesity hypoventilation syndrome (OHS). The key products/services to be delivered include:

  1. Determining the therapeutic benefits of the MC4R agonist setmelanotide in treating sleep-disordered breathing and hypercapnia in diet-induced obese mice, a model of OHS.

  2. Examining whether chemogenetic activation or inhibition of MC4R-expressing neurons in the parafacial region can mimic or attenuate the respiratory effects observed with setmelanotide.

  3. Investigating the synaptic connections between MC4R-positive parafacial neurons and respiratory premotor neurons to understand the neural mechanisms by which MC4R modulates breathing control.

The research aims to provide a rationale for developing MC4R agonists as a potential pharmacotherapy for OHS, a severe form of sleep-disordered breathing characterized by daytime hypercapnia and hypoventilation in obese individuals. The grant period runs from July 2024 to April 2025.

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