Project Grant R01HL174023
- The federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $865,286 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to develop a high-resolution spatiotemporal lineage map of cardiac development. The research aims to spatiotemporally map early cardiac progenitor lineages and their clonal relationships, map the phylogeny of major myocardial cell...
- This $506,984 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the role of the LRP1 gene in the development of congenital heart disease (CHD). The primary objectives are to: Examine the deployment and migration of cardiac neural crest cells (CNCCs) and their dependence on LRP1 using in vitro and in vivo cell lineage fate mapping analysis. Investigate the cellular and molecular...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate how signaling pathways regulate cardiac progenitor cell proliferation and lineage specification during prenatal heart development. The $439,065 award to Swarthmore College will fund a 3-year project leveraging the simplified cellular model of the marine invertebrate Ciona robusta to decipher conserved mechanisms of signal-dependent...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to understand the development of lymphovenous valves (LVVs) and their role in lymphatic dysfunction in patients with congenital heart disease (CHD). The $135,204 award to Rutgers, The State University of New Jersey will fund research to determine when cells from the second heart field (SHF) contribute to LVV development and if this SHF contribution is required for...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $540,856 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) on Dec 15, 2024. The goal of this 4-year project is to identify transcriptional regulators that control endocardial-specific gene expression and valve development, as well as understand the regulation and function of the SLC16A2 gene during heart injury and regeneration. The...
- This $1,000,000 National Science Foundation project grant supports research at the University of Wisconsin-Madison to develop single cell-level programming of human induced pluripotent stem cell differentiation into chamber-specific cardiomyocytes. The goal is to generate cardiomyocytes from each chamber of the heart through precise control of Wnt and retinoic acid signaling at the single cell level via engineered genetic programs and superstructures. If successful, this approach could establish...
- The University of California, San Diego (UCSD) was awarded a $788,513 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to study the mechanisms underlying the maintenance of cardiac chamber identity in zebrafish. The research aims to elucidate the genetic pathways that reinforce ventricular cardiomyocyte identity, as ventricular myocardium harbors considerable plasticity and can transform to acquire atrial traits under certain...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $134,998 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on July 20, 2025, will support research to define the cellular and molecular mechanisms driving the formation of the linear heart tube during embryonic development. The primary objectives are to: 1) quantitatively analyze cell movements and behaviors required for proper...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $833,594 to investigate the pro-regenerative potential of the Pontin gene in the heart. The research aims to decipher the gene regulatory networks controlling cardiomyocyte (heart muscle cell) proliferation, with the goal of identifying druggable pathways to stimulate heart regeneration as a remedy for myocardial infarction....
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
MECHANISMS OF JUXTA-CARDIAC FIELD PROGENITORS - PROJECT SUMMARY THE HEART IS COMPOSED OF A BROAD RANGE OF DIVERSE CARDIAC CELL TYPES, WHICH ORGANIZE INTO DISTINCT CARDIAC STRUCTURES THAT COORDINATELY REGULATE CARDIAC FUNCTION AND CIRCULATION THROUGHOUT THE BODY. DESPITE EFFORTS DEVOTED TOWARD UNDERSTANDING HOW THESE CARDIAC CELL TYPES ARE CREATED IN ORDER TO DEVELOP POTENTIAL HUMAN CARDIAC THERAPIES AND/OR ILLUMINATE UNDERLYING MECHANISMS/ETIOLOGIES OF CONGENITAL HEART DISEASE (CHD), OUR UNDERSTANDING OF HOW DIVERSE CARDIAC CELL TYPES EMERGE FROM DEVELOPMENTAL HEART FIELD PROGENITORS, AND HOW THEY ORGANIZE INTO HEART STRUCTURES REMAINS TO BE FULLY DEFINED. THUS, WE PROPOSE TO IDENTIFY AND INVESTIGATE THE CARDIOVASCULAR DEVELOPMENTAL REGULATORS AND GENE REGULATORY NETWORKS THAT DIRECT THE DEVELOPMENT OF JUXTA- CARDIAC FIELD (JCF)-DERIVED CARDIOVASCULAR CELL TYPES CREATING THE MAMMALIAN HEART. TOWARD THIS END, A MULTI- DISCIPLINARY EXPERIMENTAL AND COMPUTATIONAL SYSTEMS BIOLOGY APPROACH WILL BE EMPLOYED TO: (1) EXAMINE THE CONTRIBUTION OF JCF PROGENITORS TO THE DEVELOPING HEART, (2) INVESTIGATE HOW JCF PROGENITORS DIFFERENTIATE INTO SPECIFIC CELL TYPES CONTRIBUTING TO HEART DEVELOPMENT AND (3) INVESTIGATE WHETHER MECHANISMS IN JCF DEVELOPMENT ARE CONSERVED IN HUMAN HEART DEVELOPMENT.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $763.9k | 7/8/25 | ||
| Not listed | $76.4k | 6/6/24 | ||
| Not listed | $687.5k | 3/6/24 | ||
| Not listed | $687.5k | 3/6/24 |