This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $181,392 to The Leland Stanford Junior University (Stanford University) to optimize surgical techniques for congenital aortic valve disease. The research aims to leverage computational modeling and simulation to guide the design of two promising procedures: bicuspidization repair and bioprinted valve replacement. The goal is to...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $497,223 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Leland Stanford Junior University (Stanford University). The grant, titled "Exploiting Neointimal and Vascular Smooth Muscle Cell Heterogeneity to Reveal Mechanisms Driving Venous Neointimal Growth and Vascular Remodeling in Pediatric Pulmonary Hypertension," aims to advance the understanding of the cellular and molecular...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $569,891.83 to Yale University from July 1, 2024 to June 30, 2027. The goal is to develop a computational model that can predict the propensity for heart failure after myocardial infarction. This will involve refining and validating a multiscale model that combines cell-scale cardiac growth and remodeling with organ-scale cardiac...
This $760,046 federal Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a computationally-efficient multiscale modeling framework that integrates machine learning and artificial intelligence to predict structural and functional changes in the heart due to disease progression. The project aims to build fundamental understanding of heart disease by combining techniques from...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of a 3D bioprinted human heart model to study cardiomyocyte proliferation in Hypoplastic Left Heart Syndrome (HLHS). The $148,548 award to the Research Institute at Nationwide Children's Hospital aims to leverage induced pluripotent stem cell (iPSC) technology and 3D bioprinting techniques to create an in vitro HLHS model...
The University of Colorado-Denver received a $126,059 Project Grant from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a 5-year research project to investigate the systems biology of acute and chronic multi-organ failure in children with congenital heart disease (CHD).
Specifically, the research will utilize proximity extension assay technology to perform longitudinal measurement of the circulating proteome...
This $165,672 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at The Leland Stanford Junior University to investigate the role of cardiac troponin I (cTnI) in regulating mitochondrial function and its implications for inherited cardiomyopathies.
The key objectives are to: 1) determine the effects of cTnI phosphorylation and truncation on mitochondrial function, and 2) evaluate the...
This Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $200,000 to the University of Miami to develop advanced computational methods for creating high-fidelity, fast-running digital twins of patient hearts and cardiovascular medical devices. The key products to be delivered include:
Novel machine learning algorithms for accurate digital twin geometry reconstruction from 3D+T medical images,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded 3DT Holdings, LLC a $293,653 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a software tool for optimizing cardiac resynchronization therapy (CRT), conduction system pacing (CSP), and left ventricular endocardial pacing (LVEP) therapies. The project aims to leverage physics-based modeling, artificial intelligence, and machine learning to simulate the acute effects of these therapies in...
This federal Project Grant award of $673,558, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop hypoimmunogenic human pluripotent stem cell (HPSC) cardiac organoids enhanced with silicon nanowires for cardiac regenerative therapies. The central goals are to determine the effects of hypoimmunogenic gene editing on the structures and functions of HPSC cardiac organoids, as well as illustrate the...