Project Grant R01HL173611

Award Date 1/15/25
Completion Date 11/30/28
Dollars Obligated $601K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Virginia, USA
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  1. Determine the biological and molecular basis for synergy between PTPN1 deficiency and the JAK2V617F mutation in the progression of MPNs.
  2. Investigate the role of TIMP-1 and underlying molecular mechanisms in the progression of MPNs induced by JAK2V617F.
  3. Identify and test new therapeutic strategies for MPN/myelofibrosis.

The award was made to the Rector & Visitors of the University of Virginia, a public research university, and will run from January 2025 to November 2028. The research aims to provide new mechanistic insights into MPN progression and develop improved treatment approaches for these hematological malignancies.

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