The National Heart, Lung, and Blood Institute (NHLBI) awarded a $694,403 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the Arkansas Children's Research Institute (ACRI) to develop an integrated host-microbe gene classifier to predict SARS-CoV-2 and severe disease in children with respiratory viral coinfections. The award aims to identify patient features, coinfecting viruses, microbial contributions, and host responses that impact disease severity in SARS-CoV-2-infected children. ACRI will partner with the University of California, San Francisco and University of Colorado-Denver to conduct genomic analyses, bioinformatics, and biostatistical modeling as part of this multidisciplinary research project. The findings are expected to support future clinical trials evaluating treatment options based on the immunologic fingerprints identified for SARS-CoV-2 infections in children.
Generated 3/4/25, 7:21 AM