Project Grant R01HL173102
- This $689,928 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a novel method for delivering localized chelation therapy to remove arterial calcification in patients with peripheral artery disease (PAD). The project will leverage the awardee's University of Nebraska expertise in evaluating over 1,000 human lower extremity arteries and a preclinical large animal model of arterial calcification....
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $761,042 to the University of Pittsburgh to conduct research on the mechanisms driving medial arterial calcification (MAC) in peripheral artery disease (PAD). The key objectives are to: 1) define how the DNA damage response promotes vascular calcification, and 2) determine how reduced adenosine production alters arginine methylation to upregulate osteogenic gene...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $489,644 to Vanderbilt University to develop non-cytotoxic drug-coated balloon (DCB) therapies to improve long-term treatment outcomes for peripheral arterial disease (PAD). The goal is to create peptide-based DCB therapies that can be delivered during angioplasty procedures to block inflammatory signaling and inhibit smooth muscle cell proliferation, which are...
- The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $126,309 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Children's Hospital Medical Center in Cincinnati, Ohio. This 2-year research project, awarded on June 16, 2025, aims to characterize the functional role of a novel cardiac and adipose-enriched microprotein called NRAC and its involvement in lipid droplet biogenesis and lipid metabolism within the cardiovascular system. The research will...
- The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $159,980 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) for the period of March 1, 2025 to August 31, 2026. The grant will fund research to investigate the role of the protein Klotho in the pathogenesis of medial arterial calcification, which is a major risk factor for limb amputation in patients with peripheral artery disease...
- This federal Project Grant award of $687,517 from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research to elucidate the role of the gene Leiomodin1 (LMOD1) in the formation of mature blood vessels, which is critical for restoring blood flow in peripheral artery disease (PAD). The research, to be conducted by the University of Alabama at Birmingham from May 2025 to February 2030, aims to determine how LMOD1 regulates the vascular...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $762,969 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to the University of Massachusetts Medical School (UMMS) for the project "The Role of Perivascular Adipose Tissue in Atherosclerotic Cardiovascular Disease (PVAT-ASCVD)". This 5-year project aims to investigate the hypothesis that perivascular adipose tissue (PVAT) in the left internal mammary artery (LIMA) exhibits a more thermogenic...
- This Project Grant award of $528,179, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research conducted by the University of Miami to investigate reprogramming of monocytes to improve neovascularization in peripheral arterial disease and critical limb ischemia. The key objectives are to: 1) determine if extracellular vesicles mediate the systemic effects of monocyte reprogramming, and 2) investigate how reduced expression of the...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), is for the "Development of Integrated OCT/US/PAT System for Intravascular Imaging". The $617,366 award is being used to develop a multimodal intravascular imaging system incorporating optical coherence tomography (OCT), ultrasound (US), and photoacoustic tomography (PAT) technologies. The objectives are to design and construct a confocal...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $245,626 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Johns Hopkins University. The grant, with a project period from February 1, 2025 to January 31, 2027, will fund research to validate lipidomic signatures associated with right ventricular and pulmonary vascular dysfunction in pulmonary arterial hypertension (PAH). The project aims to replicate the researchers' preliminary findings on...
The National Heart, Lung, and Blood Institute awarded a $700,019 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Research Institute at Nationwide Children's Hospital in Columbus, Ohio. The grant aims to develop a novel dual-phase PET/CT imaging approach using 18F-NAF to comprehensively assess peripheral artery disease (PAD) in patients with and without diabetes. The key goals are to: 1) characterize the stages of peripheral atherosclerosis targeted by 18F-NAF using human arterial specimens, and 2) prospectively apply the dual-phase 18F-NAF PET/CT imaging to quantify muscle-specific perfusion abnormalities and vessel-specific calcium burden in PAD patients, as well as predict vessel-specific calcium progression over 1.5 years. This research aims to develop a translatable imaging paradigm that enables comprehensive assessment of multiple anatomical and physiological parameters in PAD patients, which could lead to improved treatment and outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $6.1k | 9/10/25 | ||
| Not listed | $693.9k | 9/3/25 |