The National Heart, Lung, and Blood Institute (NHLBI) awarded a $787,266.00 Project Grant under CFDA 93.837 (Cardiovascular Diseases Research) to Cedars-Sinai Medical Center. The funding will support research to better understand the role of basal-like cells in idiopathic pulmonary fibrosis (IPF) and the impact of dysregulated Wnt7a signaling on fibroblast activation and alveolar epithelial stem cell renewal. The project aims to test the hypothesis that aberrant signaling in basal-like cells promotes fibrogenesis through Wnt7a activation, leading to impaired alveolar progenitor activity and exaggerated fibroblast activation. This research will utilize human lung samples and genetically modified mouse models to investigate potential therapeutic strategies targeting the Wnt7a pathway to alleviate lung injury and prevent fibrosis in IPF. The award period is from August 1, 2024 through July 31, 2028.
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