The Washington University in St. Louis has been awarded a $623,874 project grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). This 4-year grant, awarded on December 15, 2024, will support research to uncover novel regulatory pathways and functions of the telomerase RNA component (TERC) in the hematopoietic (blood cell) system. The research aims to decipher the molecular mechanisms controlling TERC biogenesis and decay in blood cells, as well as investigate the specific functions of TERC during hematopoietic development. Unique cellular models, including human pluripotent stem cell differentiation and primary CD34+ stem cell transplantation in mice, will be leveraged to complete the proposed studies. The findings from this project are expected to advance the understanding of how mutations in TERC contribute to bone marrow failure in patients with telomere biology disorders.
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