Project Grant R01HL172926

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $772,808 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Temple University-Of The Commonwealth System of Higher Education located in Philadelphia, PA. The grant supports research to examine the role of cardiomyocyte glutamine synthesis in cardiac physiology and heart failure pathogenesis. Key objectives include determining if targeting cardiomyocyte glutamine synthesis can reduce heart failure development, ascertaining if cardiomyocyte-derived glutamine is a signal for fibroblast activation, and defining the impact of glutamine synthetase inhibition on cardiomyocyte metabolism, energetics, and redox balance. The research aims to elucidate the central role of cardiomyocyte glutamine production in heart failure and identify it as a potential therapeutic target. The grant period runs from December 15, 2024 to November 30, 2028.