The Regents of the University of Michigan was awarded a $603,504 Project Grant by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The objective of this 4-year grant is to comprehensively characterize genetic variants in the von Willebrand factor (VWF) gene that impact VWF secretion, and identify a network of genes harboring genetic variants critical for VWF secretion. The grant will leverage advanced techniques like high-throughput mutational scans and CRISPR screens in cell-based models to systematically map the functional impact of VWF gene variants and trans-regulatory genes involved in VWF biology. This research aims to improve the clinical understanding of genetic factors underlying von Willebrand disease and other cardiovascular conditions related to VWF levels. As part of this project, the University of Michigan has awarded a $97,830 subgrant to McMaster University to support the expertise of Dr. Kretz in molecular biology and high-throughput screening methodologies.
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