The University of Alabama at Birmingham (UAB) has been awarded a $644,365 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, with a start date of May 25, 2024 and a completion date of April 30, 2028, will support research focused on identifying novel strategies to mitigate cardiac damage and dysfunction following invasive pneumococcal disease. Specifically, the project will investigate the role of the S100A8/9-NLRP3-IL-1β signaling circuit and excessive recruitment of proinflammatory CCR2+ macrophages in mediating adverse cardiac remodeling after pneumonia. The findings will be validated in human cardiac tissue chip models, with the goal of informing future clinical trials to alleviate the cardiac burden for patients with community-acquired pneumonia.
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