This R01 project grant awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate sex differences in immune-stromal cell interactions that drive cardiovascular lesions in Kawasaki disease (KD) vasculitis. The $150,000 award to Cedars-Sinai Medical Center will fund studies to establish the contribution of monocytes, macrophages, neutrophils, and vascular smooth muscle cells to KD pathogenesis in male versus female mouse models. This research aims to elucidate the fundamental mechanisms underlying the sex disparity in cardiovascular lesion development observed in KD, which may inform the development of novel therapeutic approaches. The project will be conducted from September 2024 through August 2028.
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