The University of Illinois was awarded a $495,159 federal Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on September 1, 2024, supports a research project entitled "CARMIL1 and Endothelial Barrier Function Regulation". The primary objective is to investigate the role of the cytoskeletal regulatory protein CARMIL1 in maintaining pulmonary endothelial cell barrier function, with the goal of improving the understanding of mechanisms underlying acute respiratory distress syndrome (ARDS) and identifying potential new therapeutic targets. The research will employ biochemical, imaging, and functional studies to characterize how CARMIL1 influences peripheral actin structures and dynamics, as well as its effects on endothelial barrier integrity. The project will also assess the impact of CARMIL1 manipulation on lung injury in a murine model. This research has the potential to provide novel insights into the cellular mechanisms of ARDS and the relationship between CARMIL1 genetic variants and clinical outcomes.
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