The National Heart, Lung, and Blood Institute (NHLBI) awarded a $663,669 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Northeast Ohio Medical University (Neomed) to investigate the role of coronary microvascular dysfunction (CMD) in heart failure with preserved ejection fraction (HFpEF). The research aims to determine how miR-21, a microRNA, regulates coronary microvascular function, cardiac function, and remodeling in a mouse model of HFpEF induced by a high-fat, high-sugar diet. The interdisciplinary study will encompass molecular, cellular, vascular biology, physiology, and pathophysiology approaches, including tissue-specific knockouts, lineage tracing, and in vivo measurements of vasodilation and myocardial blood flow. Completion of this project may lead to a new strategy to treat microvascular dysfunction and HFpEF, potentially improving the cardiovascular prognosis for this patient population.
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