This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $703,249 to Yale University to conduct research on the signaling pathways that connect canonical Wnt signaling, HIF-1α, and regional metabolism to understand the Spemann-Mangold organizer, an iconic signaling center involved in embryonic development.
The research aims to investigate how regional metabolism in the early Xenopus embryo dictates cell fate and the specification of the Spemann-Mangold organizer, which consumes 20% more oxygen than surrounding tissue. The project will explore a signaling pathway linking Wnt signaling, HIF-1α, and "leak" metabolism in the organizer, with the goal of elucidating fundamental biological mechanisms underlying congenital heart disease and Leigh's syndrome, a mitochondrial metabolism disorder. The award has a performance period from July 2024 through April 2029.
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