Project Grant R01HD114338

Award Date 8/1/24
Completion Date 4/30/29
Dollars Obligated $2.2M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Boston, MA 02115, USA
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This Project Grant award of $2,189,195.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to develop novel MRI tools to optimize surgical planning and fetal outcomes for twin-to-twin transfusion syndrome (TTTS). The key products and services to be delivered include:

  1. Rapid visualization of placental surface vessels and umbilical cord insertions using 3D uterine reconstructions from 2D MRI images.
  2. Characterization of local placental function before and after laser ablation surgery using quantitative T2* MRI and intravoxel incoherent motion (IVIM) techniques.
  3. Calculation of fetal size discordance metrics, including intracranial, bladder and body volumes, limb biometrics, and motion statistics, before and after laser surgery.

The goal is to provide improved preoperative guidance and direct measures of placental function to enhance surgical planning and outcomes for TTTS, a serious complication affecting up to 15% of twin pregnancies. The award period runs from August 1, 2024 to April 30, 2029 and the work will be conducted by the Children's Hospital Corporation, doing business as Boston Children's Hospital.

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