Project Grant R01GM159313
- Federal Project Grant Award Summary Dartmouth College's Office of Sponsored Projects received a $2.25 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award funds the development of novel computational methods to decode the mechanisms of human diseases by reconstructing cellular proliferation, differentiation, and migration...
- Federal Project Grant Summary Dartmouth College received a $2.25 million Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with a project period extending through July 31, 2029. This R35 mechanism award supports fundamental biomedical research investigating the mechanisms by which protein glycosylation regulates cell fate specification across four distinct cell types:...
- Federal Grant Award Summary Dartmouth College received a $2.77 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 8, 2025, with completion scheduled for May 31, 2030. The award funds the establishment of a Center for Implementation Science at Dartmouth College, a multidisciplinary research initiative designed to advance implementation science—the study of methods to...
- Federal Project Grant Award Summary Dartmouth College received a $441,626 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, with a completion date of June 30, 2030. The award funds research to develop a wireless, battery-free soft implant device equipped with a protruding microneedle sensor array designed for continuous, spatiotemporal monitoring of organ physiology...
- Federal Grant Award Summary Dartmouth College received a $850,435 Project Grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074), effective June 1, 2025 through May 31, 2030. This collaborative research initiative investigates genome-wide plant signaling modules that regulate organ development, with particular focus on sulfated peptides and their interaction with plasma membrane-bound receptor-like kinases. The research leverages the non-seed model...
- Federal Project Grant Award Summary Dartmouth College received a $105,076 Project Grant awarded December 20, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Dual Function for an Effector Immunity Protein in Pseudomonas Aeruginosa Biofilm Biogenesis," supports biomedical research investigating mechanisms by which the immunity protein TSIT regulates biofilm...
- Federal Project Grant Award Summary Dartmouth College's Office of Sponsored Projects received a $246,562 Project Grant award on June 6, 2025, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on Aspergillus fumigatus diagnostics. The research project, scheduled for completion by February 28, 2027, aims to investigate how hypoxia-induced morphological variations in A. fumigatus—a common...
- This federal Project Grant award, totaling $457,378.00, was provided by the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program. The grant supports research by Dartmouth College to investigate how the rodent hippocampus learns from experience and applies that learning to new situations. The research aims to uncover principles of how brains extract generalizable knowledge, by monitoring neural activity in mice during a cognitive learning task. Additionally, the...
- Federal Project Grant Summary Dartmouth College received a $199,786 Project Grant award from the National Science Foundation (NSF) Division of Mathematical Sciences under the Mathematical and Physical Sciences program (CFDA 47.049) on August 15, 2025, with a completion date of July 31, 2028. The award supports fundamental research in combinatorial representation theory, focusing on developing algorithms and combinatorial models to decompose complex algebraic structures into irreducible...
- Federal Project Grant Award Summary Dartmouth College received a $125,888 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041—Engineering) awarded July 1, 2025, with completion targeted for June 30, 2027. The grant funds collaborative research focused on developing Photonic-Integrated-Circuit Two-Photon (PIC-2P) microscopy technology. The project addresses fundamental limitations in biological imaging by...
Dartmouth College received a $1.32 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with a completion date of February 28, 2030. The grant funds fundamental research investigating the mechanisms of SWI/SNF (Mammalian Switch/Sucrose Non-Fermentable) complex chromatin targeting selectivity. This multi-subunit, ATP-dependent chromatin remodeling complex plays pivotal roles in development and is frequently mutated in various human diseases. The research addresses a critical knowledge gap regarding how SWI/SNF precisely targets, establishes, and sustains lineage-specific enhancers and cooperates with other regulatory factors such as pioneer factors. The research project will be conducted at Dartmouth College's Hanover, New Hampshire facilities and will deliver scientific discoveries through three primary research aims: (1) deconvoluting the cooperativity and competition between SWI/SNF subcomplexes; (2) elucidating the role of SWI/SNF in three-dimensional genome architecture; and (3) exploring the role of SWI/SNF in potentiating cellular dynamics. The investigation employs an acute protein depletion model to investigate the distinct functional repertoires of the three functionally distinct major SWI/SNF subcomplexes, with the central hypothesis that subcomplexes enable precise mosaic regulation of discrete chromatin states. This fundamental research will advance understanding of chromatin remodelers' roles in both development and disease pathogenesis.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 2/18/26 | ||
| Not listed | $1.3m | 2/6/26 |