Project Grant R01GM159028
- Federal Project Grant Award Summary The University of Georgia Research Foundation, Inc. received a $160,613 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2030. This award funds fundamental research investigating chromosome-specific meiotic biology using Drosophila melanogaster as a model organism. The project will elucidate mechanisms underlying...
- Federal Grant Award Summary The University of Georgia Research Foundation, Inc. received a $372,263 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through March 31, 2029. The award funds research into the evolution of retrotransposon control mechanisms, specifically investigating how transposable elements (TEs) are naturally regulated and restrained in organisms that...
- Federal Project Grant Award Summary The University of Georgia Research Foundation, Inc. received a $377,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This award supports fundamental research merging bacteriophage biology with microbial glycobiology to advance understanding of phage-host interactions and bacterial evolution. The...
- Federal Grant Award Summary The University of Georgia Research Foundation, Inc. received a $189,854 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 8, 2025, with completion scheduled for July 31, 2028. This award supports the development of an integrated in vitro and in silico multi-modal platform designed to elucidate the relationship between cell deformability and...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a $1.94 million Project Grant on August 8, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on the regulation of mitotic DNA damage responses. The research will be conducted through July 31, 2029, at the university's University City, Missouri campus. The project investigates the molecular mechanisms controlling DNA...
- Federal Project Grant Award Summary The University of Southern California received a $451,259 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through June 30, 2029. The research project investigates heterochromatin repair mechanisms through a chromatin composition and regulation perspective, addressing a critical knowledge gap in understanding how defective double-strand...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with a completion date of February 28, 2031. This award supports fundamental research to elucidate the mechanisms of genome integrity maintenance, specifically investigating break-induced replication (BIR) at repetitive DNA sequences, with emphasis on...
- Federal Grant Award Summary Georgia Southern University Research & Service Foundation Inc. received a $507,544 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) on August 25, 2025, with a completion date of August 24, 2028. The research initiative investigates nuclear-mitochondrial genetic mismatches and their impact on mitochondrial dysfunction, utilizing Nasonia wasps as a genetic model...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $305,927 Project Grant to the University of California, Davis, effective September 1, 2025, through March 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). The research focuses on elucidating the mechanisms of homologous recombination and its role in maintaining genomic stability and preventing cancer development. The project employs a multi-disciplinary...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded $617,007 to Harvard Medical School (President and Fellows of Harvard College) on August 1, 2025, for a five-year project period concluding June 30, 2030. The project investigates the molecular mechanisms of error-prone DNA repair, specifically focusing on non-homologous end joining (NHEJ)—the primary DNA double-strand...
The University of Georgia Research Foundation, Inc. received a $300,872 Project Grant award dated March 9, 2026, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This award supports a five-year research initiative (through February 28, 2031) investigating the role of CCCTC-binding factor (CTCF) in nucleotide excision repair (NER), a critical DNA repair pathway that protects genome stability by removing bulky DNA lesions caused by ultraviolet radiation, polyaromatic hydrocarbons, and chemotherapy agents. Defects in NER are associated with severe human genetic disorders including xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. The research employs a multidisciplinary approach integrating genome editing, DNA damage and repair mapping, proteomics, three-dimensional (3D) genomics, and bioinformatics to elucidate how CTCF facilitates NER within complex three-dimensional genome organization. The project pursues three specific research aims: determining CTCF's involvement in NER subpathways and its protein interactions, delineating CTCF-mediated 3D genome reorganization in repair processes, and investigating CTCF-mediated chromatin accessibility modulation during NER. The research conducted at the University of Georgia's Athens campus will advance fundamental understanding of DNA repair mechanisms and has potential implications for developing therapeutic strategies targeting repair-deficient genetic disorders.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $300.9k | 3/6/26 |