Project Grant R01GM158967
- This $445,000 federal project grant was awarded on January 23, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research conducted by the Beckman Research Institute of the City of Hope, a nonprofit medical research organization in California, to elucidate the molecular mechanisms by which protein arginine methylation regulates gene expression, RNA metabolism, and human biology and...
- This federal Project Grant award, valued at $149,582.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project at the University of Nevada, Las Vegas (UNLV) to investigate the regulation of hematopoiesis by the EZH2-PRC2 complex. The project aims to characterize a mouse model with a gain-of-function mutation in the EZH2 gene to determine how this affects the expansion and...
- This federal Project Grant award, valued at $442,750.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the regulation of canonical and non-canonical substrates of histone lysine methyltransferases. The research aims to address key knowledge gaps in understanding the mechanisms of active chromatin inheritance and systematically investigating the importance of...
- This Project Grant award of $349,074.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the mechanisms by which lysine acetylation regulates protein function. The project aims to develop a platform for production and chemical shift characterization of acetyllysine using well-characterized systems such as ADA2/GCN5, P300, and MOF acetyltransferases and histone H3 and H4...
- This federal Project Grant award for $380,540.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, supports research to investigate the relationship between DNA methylation and microRNAs during early human embryonic stem cell lineage specification. The research program seeks to dissect the early cell fate changes due to epigenetic regulation using omics technologies, cell imaging, and transcriptional regulator...
- This federal Project Grant award, valued at $365,625.00 and issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the mechanisms by which TET family enzymes act on 5-methylcytosine in genomic DNA and to exploit these insights to devise controllable epigenome editors. The research, conducted by The Trustees of the University of Pennsylvania, will focus on understanding cytosine...
- This $147,091 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project on plasmonic nanoantenna-enhanced fluorescence immunoassay enabled by super-hydrophobic surfaces. The goal is to develop a transformative fluorescence detection technology that can achieve ultra-low and ultra-sensitive protein detection, which is crucial for early disease diagnosis. The project...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $407,562 to the University of Denver to conduct research on the molecular mechanisms of lysosome remodeling in response to cellular stress. The 5-year project, starting September 1, 2025, aims to characterize the degradation pathways of vacuole membrane proteins and investigate the transcriptional regulation of...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
This $679,856 federal project grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research into the mechanism by which lysine methylation leads to the rapid proteolysis of non-histone proteins through the ubiquitin-dependent proteolysis pathway. The research aims to investigate the dynamic methylation/demethylation process, how ubiquitin ligase complexes interact with methyl-reader proteins to target methylated substrates for proteolysis, and to develop animal models to study the biological significance of methylation-dependent proteolysis. This research could have implications for understanding the regulation of stem cells, epigenetics, chromatin remodeling, and the development of cancers and other disorders. The award was made to the University of Nevada, Las Vegas, which is part of the Nevada System of Higher Education, and has a performance period from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $679.9k | 8/27/25 |