Project Grant R01GM158795
- Federal Grant Award Summary The University of Illinois received a $396,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through June 30, 2030. This award funds fundamental research focused on developing nanophotonic technologies to probe and control chirality across molecular and cellular scales. The research addresses a critical gap in current...
- Federal Grant Award Summary The University of Illinois received a $761,271 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 1, 2025, with a completion date of June 30, 2030. This five-year research initiative, conducted at the University of Illinois Urbana campus, will deliver fundamental scientific research investigating the physiology of oxidative stress in bacteria. The project...
- Federal Grant Award Summary The University of Illinois received a $466,936 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) awarded on July 5, 2025, with a completion date of June 30, 2030. The grant supports two integrated research programs aimed at advancing chemical synthesis efficiency and selectivity for small molecule drug discovery. The first program will develop a library of stereodefined,...
- Federal Grant Award Summary The University of Chicago received a $1.97 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with completion targeted for August 31, 2029. This award supports fundamental research on multiscale simulation of key biomolecular processes in cells, specifically focusing on biological membranes, protein-protein interactions, and...
- Federal Grant Award Summary The University of Illinois received a $1.14 million Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2030. This award funds research to identify physicochemical traits that enable small molecule compounds to evade efflux pump mechanisms in gram-negative bacteria. The research will measure accumulation of...
- Federal Grant Award Summary The University of Illinois has been awarded $548,816 through the National Heart, Lung, and Blood Institute's (NHLBI) Cardiovascular Diseases Research program (CFDA 93.837), effective September 2, 2025, with completion targeted for May 31, 2029. This Project Grant supports fundamental research investigating inter-organelle communication mechanisms in lipid metabolism, specifically examining the role of the SEC16B scaffold protein in regulating very low-density...
- Federal Grant Award Summary The University of Illinois received a $475,036 Project Grant awarded on April 11, 2025, by the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports a two-year research initiative (through March 31, 2027) conducted at the Chicago, Illinois campus to investigate synergistic dual aminoglycoside antibiotic combinations targeting multidrug-resistant (MDR) gram-negative bacteria....
- Federal Project Grant Award Summary The University of Illinois received a $583,698 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through April 30, 2030. The award funds the Mera Laboratory's research initiative to decode the molecular coordination mechanisms governing the bacterial cell cycle using Caulobacter crescentus as a model organism. The research employs...
- Federal Grant Award Summary The University of Illinois received a $440,908 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 3, 2026, through January 31, 2028. The research aims to identify and develop inhibitors of bacterial peptidyl-transfer RNA (tRNA) hydrolase (PTH), an essential bacterial enzyme critical for protein synthesis. The project delivers a novel...
- Federal Project Grant Award Summary The University of Cincinnati's Sponsored Research Services Division received a $405,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This award supports fundamental research investigating the critical interaction between erythrocytes (red blood cells) and the endothelium following traumatic injury...
The University of Illinois received a $1,385,652 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2030. The award funds research to develop an innovative platform technology for in vivo metabolic tagging and targeting of red blood cell (RBC) membranes using click chemistry. The research builds on preliminary findings that RBCs can metabolize unnatural sugars and express chemical tags such as azido groups in the form of glycoproteins and glycolipids, enabling subsequent conjugation of imaging and therapeutic agents to circulating RBCs under physiological conditions. The project delivers fundamental research and technological development across three specific aims: elucidation of metabolic glycan labeling mechanisms, optimization of labeling efficiency, and evaluation of effects on RBC structure and function; exploration of in vivo metabolic labeling of circulating RBCs following intravenous administration of unnatural sugars; and development of methods for direct conjugation and targeting of molecular imaging and therapeutic cargos via click chemistry. This research addresses a significant gap in current RBC membrane engineering, which has been limited to isolated, in vitro conditions, and offers potential applications in drug delivery, immune modulation, hemostasis, and vaccination.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 3/9/26 |