This $440,454 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project to study epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The key products and services to be delivered include: Investigating how epithelial cells sense and respond to extracellular wounds with varying collagen types and matrix stiffness, and how cytoskeletal...
This $367,105 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research program focused on increasing the rigor and reproducibility of approaches to capture extracellular matrix (ECM) remodeling. The key objectives are to: (1) understand how ECM geometry and structure vary regionally at multiple scales, and (2) determine how ECM heterogeneity influences a tissue's local and global...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), awarded a $406,250 project grant to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, effective January 22, 2025 through December 31, 2029, aims to implement the nascent extracellular matrix (ECM) into the dynamic reciprocity of cell-ECM interactions in complex...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 - Biomedical Research and Research Training supports the development of new materials and technologies to study how cells sense and respond to changes in their mechanical microenvironment. The $1,218,750 award, spanning from September 1, 2024 to June 30, 2029, will enable the creation of novel bioorthogonal chemistries and protein-engineered biomaterials that can independently and...
The National Institute of General Medical Sciences (NIGMS) awarded Duke University a Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to advance the understanding of cellular mechanosensitivity. The $387,662 grant, awarded on January 1, 2025, will support research aimed at elucidating the molecular mechanisms by which cells sense and respond to mechanical cues. The project will leverage protein engineering techniques to develop biosensors that can assess...
This $393,093 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to uncover the interaction between gene expression, cell morphology, and tissue-level mechanics in embryonic development. The principal investigator, Bianca Dumitrascu, will leverage an integrative statistical machine learning framework to analyze 4D data on mammalian development across multiple species,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $406,250.00 to support research investigating the role of mechanical cues from the extracellular matrix in regulating monocyte inflammation. The project aims to develop human stem cell-based culture systems for studying monocyte mechanobiology, investigate the mechanical regulation of non-canonical NF-kappa-B...
This Project Grant award of $541,967 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports a research program at the University of Chicago to expand the understanding of adherent cell mechanics and mechanobiology. The key objectives of this 5-year research project are to explore the force-sensitive remodeling of cell-cell adhesions and its role in contact inhibition of proliferation, as well as...
This federal Project Grant award of $479,487 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support research to examine how key physical cues, including extracellular fluid viscosity, microenvironmental stiffness, and cell confinement, regulate cell responses such as migration and signaling. The project, awarded to The Johns Hopkins University, will employ cutting-edge in vitro models and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $786,132 over 5 years to Lehigh University to develop and expand computational tools and applications for the study of biological macromolecular systems. The key products and services to be delivered include: 1) Further development and expansion of the CHARMM-GUI web-based platform for constructing complex biomolecular simulation...