This $1,539,200 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports the development of an integrated technology platform to characterize the conformational flexibility, heterogeneity, and dynamics of functional oligonucleotides. The key products to be delivered include: A novel ionization technique called Capillary Vibrating Sharp-Edge Spray Ionization (CVSSI) that...
This Project Grant award, totaling $365,630.00, was made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The funding will support the development and application of machine learning models to design new nucleic acid-based imaging agents and carbohydrate-based drugs. The principal goal is to create automated high-quality datasets and multiscale models for the rational design of complex biomolecules, which can...
This $387,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support The Johns Hopkins University's work on developing computational methods for improving human gene annotation. The project aims to address systematic errors in the ability of leading transcriptome assembly and quantification methods to process the exponential growth of RNA-sequencing data. Key planned activities include...
The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California. The purpose of this grant is to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. This innovative platform will leverage enzymatic processing and advanced bioinformatics to accurately sequence peptides with...
This $540,000 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop a comprehensive framework called FZ to enable scientific users to intuitively research, compose, implement, and test specialized lossy data compression techniques. The project will build on existing capabilities from various open-source data compression tools to create an intuitive cyberinfrastructure for the composition of specialized...
The National Science Foundation Division of Information and Intelligent Systems awarded a $175,000 Project Grant to the National Center For Genome Resources of Santa Fe, New Mexico for work titled "Toward the Compression of Pangenomic DNA Sequence Data Using Context-Free Grammars." The two-year award beginning August 1, 2021 will support research under the Computer and Information Science and Engineering program (CFDA 47.070) to develop techniques for compressing large genomic sequence...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,000 SBIR Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Quantitative Biosciences, Inc. (QBiSci.com), a for-profit company in San Diego, CA. The grant aims to develop a neural network-accelerated DNA and RNA sequence processing node, called CLEDGESEQ, for distributed next-generation sequencing (NGS) data processing at the point of sequencing. The key objectives are to: 1) Develop neural...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of novel statistical and computational methods for genetic epidemiology. The $346,582 award, active from January 1, 2025 to December 31, 2029, aims to address limitations in current computational approaches for leveraging pathogen genetic data in the study and surveillance of infectious diseases....
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development of advanced computational frameworks to enhance understanding of pharmacogenomic mechanisms in complex diseases. Over the 5-year award period from September 2024 to August 2029, the key products and services to be delivered include: 1) deep learning models that integrate multi-omic data to...