Project Grant R01GM157172
Award Date 9/1/25
Completion Date 8/31/27
Dollars Obligated $616K
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Florida, USA
Similar Awards
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,125.00 to the University of Florida to conduct research aimed at "Decoding Enzyme Sequence-Activity Relationships via Generative AI for Rational Enzyme Design." The research program seeks to advance the understanding of enzyme sequence-activity relationships through the application of generative artificial...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $216,906 Project Grant to The Regents of the University of Colorado, doing business as the University of Colorado Office of Contracts and Grants Division, to conduct research on the "Evolution of Novel Metabolic Pathways" under CFDA Program 93.859 - Biomedical Research and Research Training. The funding will support the University's efforts to study how organisms can evolve new metabolic pathways to access new...
- This federal Project Grant award of $277,375.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to examine the sources, fates, and effects of compartmentalized cofactor metabolism in eukaryotic cells. The award to Temple University will allow the researchers to measure the pools of critical cofactors like acyl-CoAs across subcellular compartments and investigate their specific...
- This $378,715 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of novel aptamer-based biosensing probes for high-resolution chemical imaging of multiple analytes at the single-cell level. The Florida State University (FSU) Lazenby Lab, the awardee, is leveraging electrochemical techniques and aptamer-based sensing platforms to expand the scope of molecules...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This federal Project Grant award of $188,627, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds the development of tools to measure post-translational modification enzyme activity, with a focus on kinases. The project aims to (1) build understanding of kinase-substrate interactions using techniques like in vitro phosphoproteomics, novel substrate design, and computational methods, and (2) develop...
- This federal Project Grant award of $227,435, awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS), provides funding for research on "Genetic Constraints on Adaptive Evolution" under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the research program is to unravel how genetic constraints limit adaptation and how these constraints diverge between species. The University of Rochester, the awardee, will build on their...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
- This Project Grant award of $249,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is to support research at Duke University to expand the capabilities of enzymes beyond their natural functions for synthesizing medicinally important chemical compounds. The key products or services to be delivered include engineering heme enzymes and methionine sulfoxide reductases to catalyze aminations and oxidations,...