The National Institute of General Medical Sciences (NIGMS) awarded a $651,596 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to Cold Spring Harbor Laboratory (CSHL) to investigate the molecular underpinnings of a biological clock that coordinates cell fate specification and temporal patterning during development in the nematode C. elegans. The research aims to determine the structures of three protein complexes that regulate oscillatory microRNA transcription patterns, and to engineer targeted mutations in clock components to understand how these dynamics impact developmental processes. The study will utilize advanced imaging techniques to directly monitor changes in transcriptional dynamics and correlate them with alterations in stem cell division patterns. Additionally, the project seeks to identify ligands that coordinate the activity of the clock's transcription factors across tissues. Findings from this work could shed light on how transcriptional timing contributes to developmental robustness and how metabolism is integrated with transcriptional regulation during development. The project period runs from August 1, 2024 to July 31, 2026.
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