This $444,830 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of Florida to develop novel small molecule probes to study the precise function of the enzyme heparanase in extracellular matrix (ECM) remodeling. The research aims to yield new tools to facilitate real-time detection of heparanase activity both in vitro and in vivo, in order to better...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $379,003 to the University of Georgia Research Foundation to conduct research on the functional genomics of multiple hereditary exostoses (MHE). The goal of this 2-year project is to leverage the awardee's expertise in uncovering regulatory factors of heparan sulfate biosynthesis to adapt...
This $390,000 Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research project at Georgia State University Research Foundation Inc. to develop a versatile, small molecule-based platform to map the "reader proteins" that interact with glycans (carbohydrates) on proteins and lipids. The goal is to decipher the protein-carbohydrate interaction code, especially in the context...
This federal Project Grant award of $787,024 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research by the University of Georgia Research Foundation, Inc. to study the composition, assembly, and function of Polycomb group (PCG) repressed chromatin domains. The research aims to uncover the mechanisms controlling the establishment, spreading, and epigenetic inheritance of the H3K27me3 histone...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $471,019 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Georgia Tech Research Corporation to characterize extracellular glycoproteins and investigate their functions. The project aims to develop innovative mass spectrometry-based methods to comprehensively analyze glycoproteins on cell surfaces and in the secretome, as well as study the interactions between surface glycoproteins and...
The National Institute of General Medical Sciences (NIGMS) awarded a $388,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Hauptman Woodward Medical Research Institute, Inc., a non-profit research organization in Buffalo, New York. The grant, titled "N-GLYCOSYLATION AS A REGULATOR OF GRP94 FUNCTION AND ACTIVITY," will support a systematic analysis of how glycosylation regulates the structure and function of the ER chaperone protein...
This $344,031 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at William Marsh Rice University to improve understanding of cellular function and pathogenesis. The key objectives are to: Develop approaches for live-cell 3D tracking of specific chromosomal loci pairs, such as enhancer-promoter pairs, to uncover fundamental physical mechanisms of gene regulation. This will yield...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on exploring convergent evolution in natural product biosynthesis. The $357,125 award, spanning August 1, 2024 to May 31, 2029, will support research at the University of Georgia Research Foundation, Inc. to investigate the potential of "convergent evolution" in natural product biosynthesis as a marker...
This $148,568 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is supporting research to "Demystify the Interaction of UGGT, the ER Folding Gatekeeper, with its Substrates and Co-Chaperone". The research aims to use a combination of cellular and biophysical experiments to investigate the interactions of the UGGT enzyme, which regulates protein folding in the endoplasmic reticulum, with...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides funding of $211,988 to Emory University to characterize the functional consequences of mutations in histone genes that are implicated in human disease. The key objectives are to: Elucidate the mechanism by which the Esa1/Tip60 lysine acetyltransferase suppresses growth defects in histone H3 K36 mutant cells. This...