Project Grant R01GM153798
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $645,905 to Yale University to conduct research on the variation in chemotactic strategies across bacterial species. The key products and services to be delivered through this 5-year grant include: Using single-cell fluorescence resonance energy transfer to characterize the dynamics of chemotactic signal processing...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the structures and hydration of biopolymers (proteins, DNA, and RNA) at aqueous interfaces. The $401,571 award to Yale University aims to address fundamental questions about how the asymmetric chemical environments of interfaces impact the stability and conformational changes of biopolymers....
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), CFDA 93.859 Biomedical Research and Research Training program, provides $479,487 to The Johns Hopkins University to support research on how extracellular fluid viscosity, stiffness, and confinement regulate cell responses, particularly in the context of cell migration. The award period is from February 1, 2025 to January 31, 2030. The research aims to develop a comprehensive understanding of how...
- The federal Project Grant award of $795,230.00 from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training program, supports research at Yale University to develop chemical regulators of the YEATS4 protein to engineer cell fate plasticity. The goal is to enable more efficient conversion of somatic cells into induced pluripotent stem cells (iPSCs) using the transcription factors OCT4, SOX2, KLF4 and CMYC (OSKM). The research aims to...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $389,600.00 to Drexel University to conduct research on the physical mechanisms of 3D cell motility. The project aims to investigate how the structure of 3D extracellular matrices affects actomyosin contractility and water influx, which are essential for cell movement through 3D environments like wound healing and...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
The Federal Grant Award of $669,737.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The award, with a performance period from September 1, 2025 to August 31, 2027, supports a research project focused on investigating the principles underlying convective cell motion and its coordination with cell migration within tissues. The research aims to provide fundamental insights into biological mechanisms and suggest potential interventions for motility-associated diseases. Yale University, a prestigious private research institution, has extensive capabilities in specialized biomedical research, as demonstrated by its various federal contract and grant awards across diverse scientific domains.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $669.7k | 8/28/25 |