The National Institute of General Medical Sciences (NIGMS) awarded a $343,203 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Regents of the University of Michigan. The grant aims to elucidate the biological process of heme insertion into cytochrome P450 enzymes. The research will characterize the role of tubulin and heat shock protein 70 (HSP70) in the heme insertase machinery, as well as define the heme insertase for the CYP2E1 enzyme. This innovative research is expected to provide new tools and a better understanding of the fundamental process of heme insertion, which has implications for maintaining functional enzyme levels and the development of HSP90 inhibitor and HSP70-based therapies. The project period runs from February 1, 2025 through December 31, 2028.
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