The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit research organization based in Cheltenham, Pennsylvania. The purpose of this 5-year grant, with a period of performance from July 1, 2024 to April 30, 2029, is to conduct advanced mechanistic studies on how the cohesin complex mediates the formation of chromatin loops and domains, which are key...
The National Institute of General Medical Sciences (NIGMS) awarded a $147,900 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Sonoma State University to study chromosome organization in human somatic cells. The project aims to uncover how human somatic cells regulate proper chromosome organization during development to prevent genomic instability. Key research goals include experimentally testing hypotheses on the spatial segregation of haploid...
The National Institute of General Medical Sciences (NIGMS) awarded a $388,750 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of North Carolina at Chapel Hill (UNC-CH) to conduct research on the regulatory mechanisms governing genome folding in multicellular organisms. The project, titled "Deciphering the Stepwise Regulatory Mechanisms of Genome Folding", aims to investigate how nuclear bodies, post-translational modifications, and cytosolic...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $1,350,554 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York to conduct research on the molecular mechanisms of eukaryotic chromosome replication. The research aims to illuminate the intrinsic mechanisms of the eukaryotic DNA replication machinery and its response to various replication stress conditions, including the impact of...
The National Institute of General Medical Sciences (NIGMS) awarded a $769,496 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to New York University School of Medicine on May 10, 2024. The funding supports a 5-year research project from May 2024 through April 2029 focused on advancing the understanding of biological processes and laying the groundwork for improvements in disease diagnosis, treatment, and prevention. As a leading academic medical center and research...
This National Institute of General Medical Sciences (NIGMS) Project Grant, under the Biomedical Research and Research Training program (CFDA 93.859), provides $125,000 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the competition between chromatin modifying complexes and their impact on chromatin accessibility. The award, which runs from August 1, 2024 to July 31, 2026, aims to define the molecular mechanisms and dynamics that shape...
The National Institute of General Medical Sciences (NIGMS) awarded a $360,100 Project Grant to the Fred Hutchinson Cancer Center in Seattle, WA under the Biomedical Research and Research Training Program (CFDA 93.859). The grant, awarded on June 19, 2024, will fund research to investigate the chromatin landscape of complex tissues through cell-type-specific patterns. The project aims to advance understanding of biological processes and lay the groundwork for improvements in disease diagnosis,...
This $411,250 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate how changes in cellular metabolites, specifically polyamines, impact chromatin biology and cell fate decisions. The research seeks to understand the role of polyamines, which are present at high concentrations in eukaryotic cells, in regulating chromatin accessibility, DNA replication dynamics, and...
This $364,969 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of switchable and functional fluorophores for multi-functional super-resolution microscopy (MF-SRM) and spatially-resolved single-cell multi-omics. The grant aims to create a toolbox of fluorescent sensors as single-molecule functional probes to enable new experimental and computational studies in the...